Determining the Best Strategies for Maternally Targeted Pertussis Vaccination Using an Individual-Based Model

PT Campbell; J McVernon; N Geard

Journal article

Determining the Best Strategies for Maternally Targeted Pertussis Vaccination Using an Individual-Based Model

PT Campbell, J McVernon, N Geard

American Journal of Epidemiology | OXFORD UNIV PRESS INC | Published : 2017

DOI: 10.1093/aje/kwx002

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Abstract

Rising pertussis incidence has prompted a number of countries to implement maternally targeted vaccination strategies to protect vulnerable infants, but questions remain about the optimal design of such strategies. We simulated pertussis transmission within an individual-based model parameterized to match Australian conditions, explicitly linking infants and their mothers to estimate the effectiveness of alternative maternally targeted vaccination strategies (antenatal delivery vs. postnatal delivery) and the benefit of revaccination over the course of multiple pregnancies. For firstborn infants aged less than 2 months, antenatal immunization reduced annual pertussis incidence by 60%, from 7..

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University of Melbourne Researchers

Patricia Campbell Author

Jodie McVernon Author

Nic Geard Author

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Grants

Awarded by Australian Research Council

Funding Acknowledgements

This research was funded by the Australian Research Council (ARC) (grant DP110101758) and the National Health and Medical Research Council (NHMRC) Centre of Research Excellence (grant APP1058804). J.M. was supported by an NHMRC Career Development Fellowship (grant APP1061321). N.G. was supported by an ARC Discovery Early Career Researcher Award (grant DE130100660). Computing facilities were provided by the National eResearch Collaboration Tools and Resources (NeCTAR) Project and the Victorian Life Sciences Computation Initiative.